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Cytochrome P450 Monooxygenases for Fatty Acids and Xenobiotics in Marine Macroalgae1

Stephan Pflugmacher2 and Heinrich Sandermann Jr.*

GSF Forschungszentrum für Umwelt und Gesundheit GmbH, Institut für Biochemische Pflanzenpathologie, Ingolstädter Landstrasse 1, D-85764 Oberschleissheim, Germany

The metabolism of xenobiotics has mainly been investigated in higher plant species. We studied them in various marine macroalgae of the phyla Chlorophyta, Chromophyta, and Rhodophyta. Microsomes contained high oxidative activities for known cytochrome (Cyt) P450 substrates (fatty acids, cinnamic acid, 3- and 4-chlorobiphenyl, 2,3-dichlorobiphenyl, and isoproturon; up to 54 pkat/mg protein). The presence of Cyt P450 (approximately 50 pmol/mg protein) in microsomes of the three algal families was demonstrated by CO-difference absorption spectra. Intact algal tissue converted 3-chlorobiphenyl to the same monohydroxy-metabolite formed in vitro. This conversion was 5-fold stimulated upon addition of phenobarbital, and was abolished by the known P450 inhibitor, 1-aminobenzotriazole. It is concluded that marine macroalgae contain active species of Cyt P450 and could act as a metabolic sink for marine pollutants.

1   This work was supported in part by Limagrain (Chappes, France) and by Fonds der Chemischen Industrie (Frankfurt, Germany).
2   Present address: Institut für Gewässerökologie und Binnenfischerei, Müggelseedamm 310, D-12587 Berlin, Germany.
*   Corresponding author; e-mail sandermann{at}gsf.de; fax 49-89-3187-3383.

Plant Physiol. (1998) 117: 123-128
Copyright Clearance Center:   0032-0889/98/117/0123/06
© 1998 American Society of Plant Physiologists




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