Plant Physiol. Journal of Pharmacology and Experimental Therapeutics
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NPH4, a Conditional Modulator of Auxin-Dependent Differential Growth Responses in Arabidopsis1

Emily L. Stowe-Evans, Reneé M. Harper, Andrei V. Motchoulski, and Emmanuel Liscum*

Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211

Although sessile in nature, plants are able to use a number of mechanisms to modify their morphology in response to changing environmental conditions. Differential growth is one such mechanism. Despite its importance in plant development, little is known about the molecular events regulating the establishment of differential growth. Here we report analyses of the nph4 (nonphototropic hypocotyl) mutants of Arabidopsis that suggest that the NPH4 protein plays a central role in the modulation of auxin-dependent differential growth. Results from physiological studies demonstrate that NPH4 activity is conditionally required for a number of differential growth responses, including phototropism, gravitropism, phytochrome-dependent hypocotyl curvature, apical hook maintenance, and abaxial/adaxial leaf-blade expansion. The nph4 mutants exhibited auxin resistance and severely impaired auxin-dependent gene expression, indicating that the defects associated with differential growth likely arise because of altered auxin responsiveness. Moreover, the auxin signaling events mediating phototropism are genetically correlated with the abundance of the NPH4 protein.

1   This work was supported by grants from the National Science Foundation (NSF) (no. MCB-9723124), the U.S. Department of Agriculture (USDA)-National Research Initiative Competitive Grants Program (no. 9602628), and the University of Missouri Research Board (no. RB96-055) to E.L. E.L.S.-E. was supported by a predoctoral fellowship from the University of Missouri Maize Biology Training Program, a unit of the Department of Energy/NSF/USDA Collaborative Research in Plant Biology Program. R.M.H. was partially supported by the University of Missouri Food for the 21st Century Program.
*   Corresponding author; e-mail mliscum{at}biosci.mbp.missouri.edu; fax 1-573-882-0123.

Plant Physiol. (1998) 118: 1265-1275
Copyright Clearance Center:   0032-0889/98/118//11
© 1998 American Society of Plant Physiologists




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