|
Plant Physiol, June 2001, Vol. 126, pp. 696-706
Inventory of the Superfamily of P-Type Ion Pumps in
Arabidopsis1
Kristian B.
Axelsen and
Michael G.
Palmgren*
SwissProt Group, Swiss Institute of Bioinformatics, 1 rue Michel
Servet, CH-1211 Geneva 4, Switzerland (K.B.A.); and Plant Physiology
and Anatomy Laboratory, Department of Plant Biology, The Royal
Veterinary and Agricultural University, Thorvaldsensvej 40, DK-1871
Frederiksberg C, Copenhagen, Denmark (M.G.P.)
A total of 45 genes encoding for P-type ATPases have been
identified in the complete genome sequence of Arabidopsis. Thus, this
plant harbors a primary transport capability not seen in any other
eukaryotic organism sequenced so far. The sequences group in all five
subfamilies of P-type ATPases. The most prominent subfamilies are
P1B ATPases (heavy metal pumps; seven members), P2A and P2B ATPases (Ca2+ pumps; 14 in total), P3A ATPases (plasma membrane H+
pumps; 12 members including a truncated pump, which might represent a
pseudogene or an ATPase-like protein with an alternative function), and
P4 ATPases (12 members). P4 ATPases have been
implicated in aminophosholipid flipping but it is not known whether
this is a direct or an indirect effect of pump activity. Despite this apparent plethora of pumps, Arabidopsis appears to be lacking Na+ pumps and secretory pathway (PMR1-like)
Ca2+-ATPases. A cluster of Arabidopsis heavy metal pumps
resembles bacterial
Zn2+/Co2+/Cd2+/Pb2+
transporters. Two members of the cluster have extended C termini containing putative heavy metal binding motifs. The complete inventory of P-type ATPases in Arabidopsis is an important starting point for
reverse genetic and physiological approaches aiming at elucidating the
biological significance of these pumps.
1
The work in the laboratory of M.G.P. was
supported by the European Union's Biotechnology Program and by the
Human Frontier Science Program Organization.
*
Corresponding author; e-mail palmgren{at}biobase.dk; fax
45-3528-3365.
© 2001 American Society of Plant Physiologists
This article has been cited by other articles:
|
|
|
|
 
M. Kawachi, Y. Kobae, H. Mori, R. Tomioka, Y. Lee, and M. Maeshima
A Mutant Strain Arabidopsis thaliana that Lacks Vacuolar Membrane Zinc Transporter MTP1 Revealed the Latent Tolerance to Excessive Zinc
Plant Cell Physiol.,
June 1, 2009;
50(6):
1156 - 1170.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Chang, Y. Hu, S. Sun, Y. Zhu, G. Ma, and G. Xu
Proton pump OsA8 is linked to phosphorus uptake and translocation in rice
J. Exp. Bot.,
February 1, 2009;
60(2):
557 - 565.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E.-Y. Gong, E. Park, H. J. Lee, and K. Lee
Expression of Atp8b3 in murine testis and its characterization as a testis specific P-type ATPase
Reproduction,
February 1, 2009;
137(2):
345 - 351.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Morth, H. Poulsen, M. S Toustrup-Jensen, V. R. Schack, J. Egebjerg, J. P. Andersen, B. Vilsen, and P. Nissen
The structure of the Na+,K+-ATPase and mapping of isoform differences and disease-related mutations
Phil Trans R Soc B,
January 27, 2009;
364(1514):
217 - 227.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Moreno, L. Norambuena, D. Maturana, M. Toro, C. Vergara, A. Orellana, A. Zurita-Silva, and V. R. Ordenes
AtHMA1 Is a Thapsigargin-sensitive Ca2+/Heavy Metal Pump
J. Biol. Chem.,
April 11, 2008;
283(15):
9633 - 9641.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Wasilewska, F. Vlad, C. Sirichandra, Y. Redko, F. Jammes, C. Valon, N. F. d. Frey, and J. Leung
An Update on Abscisic Acid Signaling in Plants and More ...
Mol Plant,
March 1, 2008;
1(2):
198 - 217.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Lee, Y.-Y. Kim, Y. Lee, and G. An
Rice P1B-Type Heavy-Metal ATPase, OsHMA9, Is a Metal Efflux Protein
Plant Physiology,
November 1, 2007;
145(3):
831 - 842.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Courbot, G. Willems, P. Motte, S. Arvidsson, N. Roosens, P. Saumitou-Laprade, and N. Verbruggen
A Major Quantitative Trait Locus for Cadmium Tolerance in Arabidopsis halleri Colocalizes with HMA4, a Gene Encoding a Heavy Metal ATPase
Plant Physiology,
June 1, 2007;
144(2):
1052 - 1065.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Haydon and C. S. Cobbett
A Novel Major Facilitator Superfamily Protein at the Tonoplast Influences Zinc Tolerance and Accumulation in Arabidopsis
Plant Physiology,
April 1, 2007;
143(4):
1705 - 1719.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Adle, D. Sinani, H. Kim, and J. Lee
A Cadmium-transporting P1B-type ATPase in Yeast Saccharomyces cerevisiae
J. Biol. Chem.,
January 12, 2007;
282(2):
947 - 955.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Eren, D. C. Kennedy, M. J. Maroney, and J. M. Arguello
A Novel Regulatory Metal Binding Domain Is Present in the C Terminus of Arabidopsis Zn2+-ATPase HMA2
J. Biol. Chem.,
November 10, 2006;
281(45):
33881 - 33891.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. D. Southall, S. Terhzaz, P. Cabrero, V. R. Chintapalli, J. M. Evans, J. A. T. Dow, and S.-A. Davies
Novel subcellular locations and functions for secretory pathway Ca2+/Mn2+-ATPases
Physiol Genomics,
September 14, 2006;
26(1):
35 - 45.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. N. Talke, M. Hanikenne, and U. Kramer
Zinc-Dependent Global Transcriptional Control, Transcriptional Deregulation, and Higher Gene Copy Number for Genes in Metal Homeostasis of the Hyperaccumulator Arabidopsis halleri
Plant Physiology,
September 1, 2006;
142(1):
148 - 167.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Martinez, Y. Wang, M. A. Raimondo, J. M. Coombs, T. Barkay, and P. A. Sobecky
Horizontal Gene Transfer of PIB-Type ATPases among Bacteria Isolated from Radionuclide- and Metal-Contaminated Subsurface Soils.
Appl. Envir. Microbiol.,
May 1, 2006;
72(5):
3111 - 3118.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Dmitriev, R. Tsivkovskii, F. Abildgaard, C. T. Morgan, J. L. Markley, and S. Lutsenko
Solution structure of the N-domain of Wilson disease protein: Distinct nucleotide-binding environment and effects of disease mutations
PNAS,
April 4, 2006;
103(14):
5302 - 5307.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Baekgaard, L. Luoni, M. I. De Michelis, and M. G. Palmgren
The Plant Plasma Membrane Ca2+ Pump ACA8 Contains Overlapping as Well as Physically Separated Autoinhibitory and Calmodulin-binding Domains
J. Biol. Chem.,
January 13, 2006;
281(2):
1058 - 1065.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. K. Jakobsen,, L. R. Poulsen,, A. Schulz,, P. Fleurat-Lessard,, A. Moller,, S. Husted,, M. Schiott,, A. Amtmann,, and M. G. Palmgren,
Pollen development and fertilization in Arabidopsis is dependent on the MALE GAMETOGENESIS IMPAIRED ANTHERS gene encoding a Type V P-type ATPase
Genes & Dev.,
November 15, 2005;
19(22):
2757 - 2769.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Abdel-Ghany, P. Muller-Moule, K. K. Niyogi, M. Pilon, and T. Shikanai
Two P-Type ATPases Are Required for Copper Delivery in Arabidopsis thaliana Chloroplasts
PLANT CELL,
April 1, 2005;
17(4):
1233 - 1251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hanikenne, U. Kramer, V. Demoulin, and D. Baurain
A Comparative Inventory of Metal Transporters in the Green Alga Chlamydomonas reinhardtii and the Red Alga Cyanidioschizon merolae
Plant Physiology,
February 1, 2005;
137(2):
428 - 446.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Eren and J. M. Arguello
Arabidopsis HMA2, a Divalent Heavy Metal-Transporting PIB-Type ATPase, Is Involved in Cytoplasmic Zn2+ Homeostasis
Plant Physiology,
November 1, 2004;
136(3):
3712 - 3723.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Papoyan and L. V. Kochian
Identification of Thlaspi caerulescens Genes That May Be Involved in Heavy Metal Hyperaccumulation and Tolerance. Characterization of a Novel Heavy Metal Transporting ATPase
Plant Physiology,
November 1, 2004;
136(3):
3814 - 3823.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Armengaud, R. Breitling, and A. Amtmann
The Potassium-Dependent Transcriptome of Arabidopsis Reveals a Prominent Role of Jasmonic Acid in Nutrient Signaling
Plant Physiology,
September 1, 2004;
136(1):
2556 - 2576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Hussain, M. J. Haydon, Y. Wang, E. Wong, S. M. Sherson, J. Young, J. Camakaris, J. F. Harper, and C. S. Cobbett
P-Type ATPase Heavy Metal Transporters with Roles in Essential Zinc Homeostasis in Arabidopsis
PLANT CELL,
May 1, 2004;
16(5):
1327 - 1339.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Coombs and T. Barkay
Molecular Evidence for the Evolution of Metal Homeostasis Genes by Lateral Gene Transfer in Bacteria from the Deep Terrestrial Subsurface
Appl. Envir. Microbiol.,
March 1, 2004;
70(3):
1698 - 1707.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. J. Perez-Victoria, F. Gamarro, M. Ouellette, and S. Castanys
Functional Cloning of the Miltefosine Transporter: A NOVEL P-TYPE PHOSPHOLIPID TRANSLOCASE FROM LEISHMANIA INVOLVED IN DRUG RESISTANCE
J. Biol. Chem.,
December 12, 2003;
278(50):
49965 - 49971.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Hall and L. E. Williams
Transition metal transporters in plants
J. Exp. Bot.,
December 1, 2003;
54(393):
2601 - 2613.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Hou and B. Mitra
The Metal Specificity and Selectivity of ZntA from Escherichia coli Using the Acylphosphate Intermediate
J. Biol. Chem.,
August 1, 2003;
278(31):
28455 - 28461.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Baxter, J. Tchieu, M. R. Sussman, M. Boutry, M. G. Palmgren, M. Gribskov, J. F. Harper, and K. B. Axelsen
Genomic Comparison of P-Type ATPase Ion Pumps in Arabidopsis and Rice
Plant Physiology,
June 1, 2003;
132(2):
618 - 628.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Shikanai, P. Muller-Moule, Y. Munekage, K. K. Niyogi, and M. Pilon
PAA1, a P-Type ATPase of Arabidopsis, Functions in Copper Transport in Chloroplasts
PLANT CELL,
June 1, 2003;
15(6):
1333 - 1346.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
N.-H. Cheng, J. K. Pittman, B. J. Barkla, T. Shigaki, and K. D. Hirschi
The Arabidopsis cax1 Mutant Exhibits Impaired Ion Homeostasis, Development, and Hormonal Responses and Reveals Interplay among Vacuolar Transporters
PLANT CELL,
February 1, 2003;
15(2):
347 - 364.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Tong, S. Nakashima, M. Shibasaka, M. Katsuhara, and K. Kasamo
A Novel Histidine-Rich CPx-ATPase from the Filamentous Cyanobacterium Oscillatoria brevis Related to Multiple-Heavy-Metal Cotolerance
J. Bacteriol.,
September 15, 2002;
184(18):
5027 - 5035.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Wu, F. Liang, B. Hong, J. C. Young, M. R. Sussman, J. F. Harper, and H. Sze
An Endoplasmic Reticulum-Bound Ca2+/Mn2+ Pump, ECA1, Supports Plant Growth and Confers Tolerance to Mn2+ Stress
Plant Physiology,
September 1, 2002;
130(1):
128 - 137.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. R. Ordenes, F. C. Reyes, D. Wolff, and A. Orellana
A Thapsigargin-Sensitive Ca2+ Pump Is Present in the Pea Golgi Apparatus Membrane
Plant Physiology,
August 1, 2002;
129(4):
1820 - 1828.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. R. Cronin, R. Rao, and R. Y. Hampton
Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis
J. Cell Biol.,
June 10, 2002;
157(6):
1017 - 1028.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. O. Facanha, H. Appelgren, M. Tabish, L. Okorokov, and K. Ekwall
The endoplasmic reticulum cation P-type ATPase Cta4p is required for control of cell shape and microtubule dynamics
J. Cell Biol.,
June 10, 2002;
157(6):
1029 - 1040.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Sanders, J. Pelloux, C. Brownlee, and J. F. Harper
Calcium at the Crossroads of Signaling
PLANT CELL,
May 1, 2002;
14(90001):
S401 - 417.
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Grass, M. D. Wong, B. P. Rosen, R. L. Smith, and C. Rensing
ZupT Is a Zn(II) Uptake System in Escherichia coli
J. Bacteriol.,
February 1, 2002;
184(3):
864 - 866.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Maser, S. Thomine, J. I. Schroeder, J. M. Ward, K. Hirschi, H. Sze, I. N. Talke, A. Amtmann, F. J.M. Maathuis, D. Sanders, et al.
Phylogenetic Relationships within Cation Transporter Families of Arabidopsis
Plant Physiology,
August 1, 2001;
126(4):
1646 - 1667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z.-j. Hou, S. Narindrasorasak, B. Bhushan, B. Sarkar, and B. Mitra
Functional Analysis of Chimeric Proteins of the Wilson Cu(I)-ATPase (ATP7B) and ZntA, a Pb(II)/Zn(II)/Cd(II)-ATPase from Escherichia coli
J. Biol. Chem.,
October 26, 2001;
276(44):
40858 - 40863.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
