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Plant Physiol, June 2001, Vol. 126, pp. 811-825

Genetic Control of Natural Variation in Arabidopsis Glucosinolate Accumulation

Daniel J. Kliebenstein, Juergen Kroymann, Paul Brown, Antje Figuth, Deana Pedersen, Jonathan Gershenzon, and Thomas Mitchell-Olds*

Departments of Genetics and Evolution (D.J.K., J.K., A.F., D.P., T.M.-O.) and Plant Biochemistry (P.B., J.G.), Max Planck Institute of Chemical Ecology, Carl Zeiss Promenade 10, 07745 Jena, Germany

Glucosinolates are biologically active secondary metabolites of the Brassicaceae and related plant families that influence plant/insect interactions. Specific glucosinolates can act as feeding deterrents or stimulants, depending upon the insect species. Hence, natural selection might favor the presence of diverse glucosinolate profiles within a given species. We determined quantitative and qualitative variation in glucosinolates in the leaves and seeds of 39 Arabidopsis ecotypes. We identified 34 different glucosinolates, of which the majority are chain-elongated compounds derived from methionine. Polymorphism at only five loci was sufficient to generate 14 qualitatitvely different leaf glucosinolate profiles. Thus, there appears to be a modular genetic system regulating glucosinolate profiles in Arabidopsis. This system allows the rapid generation of new glucosinolate combinations in response to changing herbivory or other selective pressures. In addition to the qualitative variation in glucosinolate profiles, we found a nearly 20-fold difference in the quantity of total aliphatic glucosinolates and were able to identify a single locus that controls nearly three-quarters of this variation.

* Corresponding author; e-mail tmo{at}ice.mpg.de; fax 49-3641-643668.

© 2001 American Society of Plant Physiologists


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