First published online September 6, 2002; 10.1104/pp.006478
Plant Physiol, October 2002, Vol. 130, pp. 639-648
Transcription Factor CBF4 Is a Regulator of Drought Adaptation in
Arabidopsis1
Volker
Haake,2
Daniel
Cook,2
José
Luis
Riechmann,
Omaira
Pineda,
Michael F.
Thomashow, and
James Z.
Zhang*
Mendel Biotechnology, 21375 Cabot Boulevard, Hayward, California
94545 (V.H., J.L.R., O.P., J.Z.Z.); and Michigan State
University-Department of Energy Plant Research Lab (D.C.,
M.F.T.) and Department of Crop and Soil Sciences (M.F.T.), Michigan
State University, East Lansing, Michigan 48824
In plants, low temperature and dehydration activate a set of
genes containing C-repeat/dehydration-responsive elements in their
promoter. It has been shown previously that the Arabidopsis CBF/DREB1
transcription activators are critical regulators of gene expression in
the signal transduction of cold acclimation. Here, we report the
isolation of an apparent homolog of the CBF/DREB1 proteins (CBF4) that
plays the equivalent role during drought adaptation. In contrast to the
three already identified CBF/DREB1 homologs, which are induced under
cold stress, CBF4 gene expression is up-regulated by drought stress,
but not by low temperature. Overexpression of CBF4 in transgenic
Arabidopsis plants results in the activation of
C-repeat/dehydration-responsive element containing downstream genes
that are involved in cold acclimation and drought adaptation. As a
result, the transgenic plants are more tolerant to freezing and drought
stress. Because of the physiological similarity between freezing and
drought stress, and the sequence and structural similarity of the
CBF/DREB1 and the CBF4 proteins, we propose that the plant's response
to cold and drought evolved from a common CBF-like transcription
factor, first through gene duplication and then through promoter evolution.
1
This work was supported in part by the
National Science Foundation (grant no. 9983311 to J.Z.Z.), by the
Department of Energy (grant no. DEFG0291ER20021 to M.F.T.), and
by the Michigan Agricultural Experiment Station (to M.F.T.).
2
These authors contributed equally to the paper.
*
Corresponding author; e-mail jzhang{at}mendelbio.com; fax
510-264-0254.
© 2002 American Society of Plant Physiologists
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