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Plant Physiol, March 2003, Vol. 131, pp. 1027-1032

Identification and Characterization of Nodulation-Signaling Pathway 2, a Gene of Medicago truncatula Involved in Nod Factor Signaling1

Giles E.D. Oldroyd2 and Sharon R. Long*

Department of Biological Sciences, Stanford University, Stanford, California 94305-5020

Bacterially derived Nod factor is critical in the establishment of the legume/rhizobia symbiosis. Understanding the mechanisms of Nod factor perception and signal transduction in the plant will greatly advance our understanding of this complex interaction. Here, we describe the identification of a new locus, nodulation-signaling pathway 2 (NSP2), of Medicago truncatula that is involved in Nod factor signaling. Mutants at this locus are blocked for Nod factor-induced gene expression and show a reduced root hair deformation response. nsp2 plants also show a complete absence of infection and cortical cell division following Sinorhizobium meliloti inoculation. Nod factor-induced calcium spiking, one of the earliest responses tested, is still functional in these mutant plants. We conclude that the gene NSP2 is a component of the Nod factor signal transduction pathway that lies downstream of the calcium-spiking response.

1 This work was supported in part by the Howard Hughes Medical Institute and the Department of Energy (grant no. DE-FG03-90ER20010).

2 Present address: John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK.

* Corresponding author; e-mail srl{at}stanford.edu; fax 650-725-8309.

© 2003 American Society of Plant Biologists


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