First published online June 5, 2003; 10.1104/pp.103.020644
Plant Physiology 132:1315-1321 (2003)
© 2003 American Society of Plant Biologists
CELL BIOLOGY AND SIGNAL TRANSDUCTION
Arabidopsis D-Type Cyclin CYCD4;1 Is a Novel Cyclin Partner of B2-Type Cyclin-Dependent Kinase1
Atsushi Kono,
Chikage Umeda-Hara,
Jeongkyung Lee,
Masaki Ito,
Hirofumi Uchimiya and
Masaaki Umeda*
Institute of Molecular and Cellular Biosciences, The University of Tokyo,
Yayoi 1–1–1, Bunkyo-ku, Tokyo 113–0032, Japan (A.K.,
C.U.-H., J.L., H.U., M.U.); Laboratory of Plant Molecular Genetics, Graduate
School of Agricultural and Life Sciences, The University of Tokyo, Yayoi
1–1–1, Bunkyo-ku, Tokyo 113–8657, Japan (J.L.); and
Department of Biological Sciences, Graduate School of Science, The University
of Tokyo, Hongo 7–3–1, Bunkyo-ku, Tokyo 113–0033, Japan
(M.I.)
B-type cyclin-dependent kinases (CDKs) are unique to plants and are assumed
to be involved in the control of the G2-to-M phase progression and mitotic
events. However, little is known about their cyclin partners. In Arabidopsis,
we isolated cDNA encoding the D-type cyclin CYCD4;1 by a yeast
(Saccharomyces cerevisiae) two-hybrid screening using CDKB2;1 as
bait. In vitro pull-down assay showed that CYCD4;1 bound to CDKB2;1 and
CDKA;1. Protein complexes of CYCD4;1-CDKA;1 and CYCD4;1-CDKB2;1 in insect
cells exhibited histone H1-kinase activity. Promoter analysis using the
luciferase reporter gene showed that CDKB2;1 was expressed from early
G2 to M phase, whereas CYCD4;1 was expressed throughout the cell
cycle. In situ hybridization of plant tissues revealed that both
CDKB2;1 and CYCD4;1 transcripts accumulated in the shoot
apical meristem, leaf primordia, vasculature of leaves, and tapetal cells in
anthers. Our results suggest that CDKB2;1 and CYCD4;1 may form an active
kinase complex during G2/M phase and control the development of particular
tissues.
Article, publication date, and citation information can be found at
www.plantphysiol.org/cgi/doi/10.1104/pp.103.020644.
1 This work was supported by a Grant-in-Aid for Scientific Research on
Priority Areas (grant no. 14036212) and by Research for the Future from the
Japan Society for the Promotion of Science.
*
Corresponding author; e-mail
mumeda{at}imcbns.iam.u-tokyo.ac.jp;
fax 81–3–5841–8466.
Received January 20, 2003;
returned for revision March 15, 2003;
accepted March 29, 2003.
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