First published online March 29, 2004; 10.1104/pp.103.022160
Plant Physiology 134:1268-1282 (2004)
© 2004 American Society of Plant Biologists
The Arabidopsis Cyclophilin Gene Family1
Patrick G.N. Romano*,
Peter Horton and
Julie E. Gray
Robert Hill Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
Database searching has allowed the identification of a number of previously unreported single and multidomain isoform members of the Arabidopsis cyclophilin gene family. In addition to the cyclophilin-like peptidyl-prolyl cis-trans isomerase domain, the latter contain a variety of other domains with characterized functions. Transcriptional analysis showed they are expressed throughout the plant, and different isoforms are present in all parts of the cell including the cytosol, nucleus, mitochondria, secretory pathway, and chloroplast. The abundance and diversity of cyclophilin isoforms suggests that, like their animal counterparts, plant cyclophilins are likely to be important proteins involved in a wide variety of cellular processes. As well as fulfilling the basic role of protein folding, they may also play important roles in mRNA processing, protein degradation, and signal transduction and thus may be crucial during both development and stress responsiveness.
1 This work was supported by the Natural Environment Research Council and by the Biotechnology and Biological Sciences Research Council.
Article, publication date, and citation information can be found at www.plantphysiol.org/cgi/doi/10.1104/pp.103.022160.
* Corresponding author; e-mail p.romano{at}sheffield.ac.uk; fax 44–114–2222712.
Received February 14, 2003;
returned for revision March 31, 2003;
accepted June 9, 2003.
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