Plant Physiol. Journal of Pharmacology and Experimental Therapeutics
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First published online April 2, 2004; 10.1104/pp.103.035873

Plant Physiology 134:1527-1535 (2004)
© 2004 American Society of Plant Biologists

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CELL BIOLOGY AND SIGNAL TRANSDUCTION

Phytohormones Participate in an S6 Kinase Signal Transduction Pathway in Arabidopsis1

Franziska Turck2,*, Frederic Zilbermann, Sara C. Kozma, George Thomas and Ferenc Nagy

Friedrich Miescher Institute, CH–4002 Basel, Switzerland (F.T., F.Z., S.C.K., G.T.); and Plant Biology Institute, Biological Research Center, H–6701 Szeged, Hungary (F.N.)

Addition of fresh medium to stationary cells of Arabidopsis suspension culture induces increased phosphorylation of the S6 ribosomal protein and activation of its cognate kinase, AtS6k. Analysis of the activation response revealed that medium constituents required for S6 kinase activation were the phytohormones 1-naphthylacetic acid (auxin) and kinetin. Pretreatment of cells with anti-auxin or PI3-kinase drugs inhibited this response. Consistent with these findings, LY294002, a PI3-kinase inhibitor, efficiently suppressed phytohormone-induced S6 phosphorylation and translational up-regulation of ribosomal protein S6 and S18A mRNAs without affecting global translation. These data indicate that (1) activation of AtS6k is regulated by phytohormones, at least in part, via a lipid kinase-dependent pathway, that (2) the translational regulation of ribosomal proteins appears to be conserved throughout the plant and animal kingdom, and that (3) these events are hallmarks of a growth-related signal transduction pathway novel in plants.

1 This work was supported the Deutscher Akademischer Austauschdienst (fellowship to F.T.) and partially by the Howard Hughes Medical Institute (International Research Scholar Award to F.N.), the Swiss National Foundation for Science (grant to S.C.K. and F.N.), and the Human Frontier Science Program and European Economic Community (grants to G.T.).

2 Present address: Max Planck Institute for Plant Breeding, Carl-von-Linné-Weg 10, D–50829 Köln, Germany.

Article, publication date, and citation information can be found at www.plantphysiol.org/cgi/doi/10.1104/pp.103.035873.

* Corresponding author; e-mail turck{at}mpiz-koeln.mpg.de; fax +49 221 5062207.

Received November 10, 2003; returned for revision January 8, 2004; accepted January 8, 2004.




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