First published online June 4, 2004; 10.1104/pp.104.044495
Plant Physiology 135:1020-1026 (2004)
© 2004 American Society of Plant Biologists
DEVELOPMENT AND HORMONE ACTION
AtCAND1, A HEAT-Repeat Protein That Participates in Auxin Signaling in Arabidopsis1
Youfa Cheng,
Xinhua Dai and
Yunde Zhao*
Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093–0116
Auxin affects many aspects of plant growth and development. We previously used chemical genetics to dissect auxin-signaling mechanisms and identified a small molecule, sirtinol, that constitutively activated auxin signaling (Y. Zhao et al. [2003], Science 301: 1107–1110). Here we describe the isolation, characterization, and cloning of an Arabidopsis mutant Atcand1-1 that emerged from a genetic screen for mutants insensitive to sirtinol. Loss-of-function mutants of AtCAND1 were resistant to sirtinol and auxin, but not to gibberellins or brassinolide. Atcand1 displayed developmental phenotypes similar to those of axr1, namely, short petioles, downwardly curling leaves, short inflorescence, and reduced fertility. AtCAND1 is homologous to human CAND1, a protein that is composed almost entirely of HEAT-repeat units and has been implicated in regulating the assembly and disassembly of the SCF protein degradation machinery. Taken together with previous biochemical studies, this work helps to elucidate the roles of AtCAND1 in protein degradation and auxin signaling.
1 This work was supported by the National Institutes of Health (grant no. 1RO1GM68631–01 to Y. Z.).
Article, publication date, and citation information can be found at www.plantphysiol.org/cgi/doi/10.1104/pp.104.044495.
* Corresponding author; e-mail yzhao{at}biomail.ucsd.edu; fax 858–534–7108.
Received March 24, 2004;
returned for revision April 13, 2004;
accepted April 15, 2004.
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