Plant Physiology 136:2621-2632 (2004)
© 2004 American Society of Plant Biologists
BIOINFORMATICS
GENEVESTIGATOR. Arabidopsis Microarray Database and Analysis Toolbox1,[w]
Philip Zimmermann2,
Matthias Hirsch-Hoffmann2,
Lars Hennig and
Wilhelm Gruissem*
Institute of Plant Sciences, Swiss Federal Institute of Technology and Zurich-Basel Plant Science Center, ETH Center, CH8092 Zurich, Switzerland (P.Z., M.H.-H., L.H., W.G.); and Functional and Genomics Center Zurich, UNI Irchel, Y32 H52, CH8057 Zurich, Switzerland (W.G.)
High-throughput gene expression analysis has become a frequent and powerful research tool in biology. At present, however, few software applications have been developed for biologists to query large microarray gene expression databases using a Web-browser interface. We present GENEVESTIGATOR, a database and Web-browser data mining interface for Affymetrix GeneChip data. Users can query the database to retrieve the expression patterns of individual genes throughout chosen environmental conditions, growth stages, or organs. Reversely, mining tools allow users to identify genes specifically expressed during selected stresses, growth stages, or in particular organs. Using GENEVESTIGATOR, the gene expression profiles of more than 22,000 Arabidopsis genes can be obtained, including those of 10,600 currently uncharacterized genes. The objective of this software application is to direct gene functional discovery and design of new experiments by providing plant biologists with contextual information on the expression of genes. The database and analysis toolbox is available as a community resource at https://www.genevestigator.ethz.ch.
1 This work was supported by ETH, Strategic Excellence Project 27421302/TH8/022, and by the Functional Genomics Center Zurich.
2 These authors contributed equally to the paper.
[w] The online version of this article contains Web-only data.
www.plantphysiol.org/cgi/doi/10.1104/pp.104.046367.
* Corresponding author; e-mail wilhelm.gruissem{at}ipw.biol.ethz.ch; fax 4116321079.
Received May 14, 2004;
returned for revision July 12, 2004;
accepted July 16, 2004.
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K. Ohyama, M. Suzuki, J. Kikuchi, K. Saito, and T. Muranaka
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P. Bednarek, M. Pislewska-Bednarek, A. Svatos, B. Schneider, J. Doubsky, M. Mansurova, M. Humphry, C. Consonni, R. Panstruga, A. Sanchez-Vallet, et al.
A Glucosinolate Metabolism Pathway in Living Plant Cells Mediates Broad-Spectrum Antifungal Defense
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W. Van den Ende and R. Valluru
Sucrose, sucrosyl oligosaccharides, and oxidative stress: scavenging and salvaging?
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Y. Sawada, K. Akiyama, A. Sakata, A. Kuwahara, H. Otsuki, T. Sakurai, K. Saito, and M. Y. Hirai
Widely Targeted Metabolomics Based on Large-Scale MS/MS Data for Elucidating Metabolite Accumulation Patterns in Plants
Plant Cell Physiol.,
January 1, 2009;
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[Abstract]
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Y. Ogata, N. Sakurai, K. Aoki, H. Suzuki, K. Okazaki, K. Saito, and D. Shibata
KAGIANA: An Excel-Based Tool for Retrieving Summary Information on Arabidopsis Genes
Plant Cell Physiol.,
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J. Luo, C. Fuell, A. Parr, L. Hill, P. Bailey, K. Elliott, S. A. Fairhurst, C. Martin, and A. J. Michael
A Novel Polyamine Acyltransferase Responsible for the Accumulation of Spermidine Conjugates in Arabidopsis Seed
PLANT CELL,
January 1, 2009;
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[Abstract]
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J. C. Schoning, C. Streitner, I. M. Meyer, Y. Gao, and D. Staiger
Reciprocal regulation of glycine-rich RNA-binding proteins via an interlocked feedback loop coupling alternative splicing to nonsense-mediated decay in Arabidopsis
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[Abstract]
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A. Fukushima, M. Wada, S. Kanaya, and M. Arita
SVD-based Anatomy of Gene Expressions for Correlation Analysis in Arabidopsis thaliana
DNA Res,
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T. Ischebeck, I. Stenzel, and I. Heilmann
Type B Phosphatidylinositol-4-Phosphate 5-Kinases Mediate Arabidopsis and Nicotiana tabacum Pollen Tube Growth by Regulating Apical Pectin Secretion
PLANT CELL,
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[Abstract]
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A. L. Schapire, B. Voigt, J. Jasik, A. Rosado, R. Lopez-Cobollo, D. Menzel, J. Salinas, S. Mancuso, V. Valpuesta, F. Baluska, et al.
Arabidopsis Synaptotagmin 1 Is Required for the Maintenance of Plasma Membrane Integrity and Cell Viability
PLANT CELL,
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[Abstract]
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L. Palmieri, A. Santoro, F. Carrari, E. Blanco, A. Nunes-Nesi, R. Arrigoni, F. Genchi, A. R. Fernie, and F. Palmieri
Identification and Characterization of ADNT1, a Novel Mitochondrial Adenine Nucleotide Transporter from Arabidopsis
Plant Physiology,
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[Abstract]
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H. Eubel, E. H. Meyer, N. L. Taylor, J. D. Bussell, N. O'Toole, J. L. Heazlewood, I. Castleden, I. D. Small, S. M. Smith, and A. H. Millar
Novel Proteins, Putative Membrane Transporters, and an Integrated Metabolic Network Are Revealed by Quantitative Proteomic Analysis of Arabidopsis Cell Culture Peroxisomes
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K. Loizeau, V. De Brouwer, B. Gambonnet, A. Yu, J.-P. Renou, D. Van Der Straeten, W. E. Lambert, F. Rebeille, and S. Ravanel
A Genome-Wide and Metabolic Analysis Determined the Adaptive Response of Arabidopsis Cells to Folate Depletion Induced by Methotrexate
Plant Physiology,
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E. A. Ananieva, G. E. Gillaspy, A. Ely, R. N. Burnette, and F. L. Erickson
Interaction of the WD40 Domain of a Myoinositol Polyphosphate 5-Phosphatase with SnRK1 Links Inositol, Sugar, and Stress Signaling
Plant Physiology,
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F. J. Sandoval, Y. Zhang, and S. Roje
Flavin Nucleotide Metabolism in Plants: MONOFUNCTIONAL ENZYMES SYNTHESIZE FAD IN PLASTIDS
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N. Q. Phan, S.-J. Kim, and D. C. Bassham
Overexpression of Arabidopsis Sorting Nexin AtSNX2b Inhibits Endocytic Trafficking to the Vacuole
Mol Plant,
November 1, 2008;
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[Abstract]
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M. Dunkel, A. Latz, K. Schumacher, T. Muller, D. Becker, and R. Hedrich
Targeting of Vacuolar Membrane Localized Members of the TPK Channel Family
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A. S. Buchovsky, B. Strasser, P. D. Cerdan, and J. J. Casal
Suppression of Pleiotropic Effects of Functional CRYPTOCHROME Genes by TERMINAL FLOWER 1
Genetics,
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R. Blanvillain, L. C. Boavida, S. McCormick, and D. W. Ow
EXPORTIN1 Genes Are Essential for Development and Function of the Gametophytes in Arabidopsis thaliana
Genetics,
November 1, 2008;
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[Abstract]
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B. Fode, T. Siemsen, C. Thurow, R. Weigel, and C. Gatz
The Arabidopsis GRAS Protein SCL14 Interacts with Class II TGA Transcription Factors and Is Essential for the Activation of Stress-Inducible Promoters
PLANT CELL,
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[Abstract]
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E. Sousa, B. Kost, and R. Malho
Arabidopsis Phosphatidylinositol-4-Monophosphate 5-Kinase 4 Regulates Pollen Tube Growth and Polarity by Modulating Membrane Recycling
PLANT CELL,
November 1, 2008;
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[Abstract]
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C. Polge, M. Jossier, P. Crozet, L. Gissot, and M. Thomas
{beta}-Subunits of the SnRK1 Complexes Share a Common Ancestral Function Together with Expression and Function Specificities; Physical Interaction with Nitrate Reductase Specifically Occurs via AKIN{beta}1-Subunit
Plant Physiology,
November 1, 2008;
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[Abstract]
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R. Galletti, C. Denoux, S. Gambetta, J. Dewdney, F. M. Ausubel, G. De Lorenzo, and S. Ferrari
The AtrbohD-Mediated Oxidative Burst Elicited by Oligogalacturonides in Arabidopsis Is Dispensable for the Activation of Defense Responses Effective against Botrytis cinerea
Plant Physiology,
November 1, 2008;
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[Abstract]
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J. Li, B. G. Hansen, J. A. Ober, D. J. Kliebenstein, and B. A. Halkier
Subclade of Flavin-Monooxygenases Involved in Aliphatic Glucosinolate Biosynthesis
Plant Physiology,
November 1, 2008;
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[Abstract]
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