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BIOINFORMATICS-PLANT DATABASES

Plant Protein Annotation in the UniProt Knowledgebase¹

Swiss Institute of Bioinformatics (M.S., A.B.), and Department of Structural Biology and Bioinformatics (A.B.), Centre Medical Universitaire, University of Geneva, 1211 Geneva 4, Switzerland; Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20057–1414 (C.H.W.); and European Molecular Biology Laboratory Outstation, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, United Kingdom (R.A.)

The Swiss-Prot, TrEMBL, Protein Information Resource (PIR), and DNA Data Bank of Japan (DDBJ) protein database activities have united to form the Universal Protein Resource (UniProt) Consortium. UniProt presents three database layers: the UniProt Archive, the UniProt Knowledgebase (UniProtKB), and the UniProt Reference Clusters. The UniProtKB consists of two sections: UniProtKB/Swiss-Prot (fully manually curated entries) and UniProtKB/TrEMBL (automated annotation, classification and extensive cross-references). New releases are published fortnightly. A specific Plant Proteome Annotation Program (http://www.expasy.org/sprot/ppap/) was initiated to cope with the increasing amount of data produced by the complete sequencing of plant genomes. Through UniProt, our aim is to provide the scientific community with a single, centralized, authoritative resource for protein sequences and functional information that will allow the plant community to fully explore and utilize the wealth of information available for both plant and nonplant model organisms.

www.plantphysiol.org/cgi/doi/10.1104/pp.104.058933.

^* Corresponding author; e-mail michel.schneider{at}isb-sib.ch; fax 41–22–379–58–58.

Received December 23, 2004; returned for revision March 9, 2005; accepted March 21, 2005.

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