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First published online April 20, 2007; 10.1104/pp.107.097097 Plant Physiology 144:623-636 (2007) © 2007 American Society of Plant Biologists OPEN ACCESS ARTICLE
Molecular Evolution of Lysin Motif-Type Receptor-Like Kinases in Plants1,[W],[OA]Division of Plant Sciences and National Center for Soybean Biotechnology (X.-C.Z., X.W., S.F., J.W., M.L., H.T.N., G.S.) and Division of Biochemistry, Department of Molecular Microbiology and Immunology (G.S.), University of Missouri, Columbia, Missouri 65211; and United States Department of Agriculture-Agricultural Research Service and Department of Agronomy, Iowa State University, Ames, Iowa 50011 (S.B.C.)
The lysin motif (LysM) domain is an ancient and ubiquitous protein module that binds peptidoglycan and structurally related molecules. A genomic survey in a large number of species spanning all kingdoms reveals that the combination of LysM and receptor kinase domains is present exclusively in plants. However, the particular biological functions and molecular evolution of this gene family remain largely unknown. We show that LysM domains in plant LysM proteins are highly diversified and that a minimum of six distinct types of LysM motifs exist in plant LysM kinase proteins and five additional types of LysM motifs exist in nonkinase plant LysM proteins. Further, motif similarities suggest that plant LysM motifs are ancient. Although phylogenetic signals are not sufficient to resolve the earliest relationships, plant LysM motifs may have arisen through common ancestry with LysM motifs in other kingdoms. Within plants, the gene family has evolved through local and segmental duplications. The family has undergone further duplication and diversification in legumes, where some LysM kinase genes function as receptors for bacterial nodulation factor. Two pairs of homeologous regions were identified in soybean (Glycine max) based on microsynteny and fluorescence in situ hybridization. Expression data show that most plant LysM kinase genes are expressed predominantly in the root and that orthologous LysM kinase genes share similar tissue expression patterns. We also examined synteny around plant LysM kinase genes to help reconstruct scenarios for the evolution of this important gene family.
1 This work was supported by the U.S. Department of Energy, Energy Biosciences Program, Office of Basic Energy Sciences (grant no. DE–FG02–02ER15309 to G.S.) and the Missouri Soybean Merchandising Council, and by the U.S. Department of Agriculture-Cooperative State Research, Education, and Extension Service (grant to the National Center for Soybean Biotechnology). Bacterial artificial chromosome sequencing at the Arizona Genomics Institute was supported by the National Science Foundation, Plant Genome Program (grant no. 0501877). The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (www.plantphysiol.org) is: Xue-Cheng Zhang (zhangxuec{at}missouri.edu). [W] The online version of this article contains Web-only data. [OA] Open Access articles can be viewed online without a subscription. www.plantphysiol.org/cgi/doi/10.1104/pp.107.097097 * Corresponding author; e-mail zhangxuec{at}missouri.edu; fax 573–884–9676. Received January 31, 2007; accepted April 6, 2007; published April 20, 2007. This article has been cited by other articles:
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