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First published online January 4, 2008; 10.1104/pp.107.113654

Plant Physiology 146:1109-1116 (2008)
© 2008 American Society of Plant Biologists

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CELL BIOLOGY AND SIGNAL TRANSDUCTION

Two Class XI Myosins Function in Organelle Trafficking and Root Hair Development in Arabidopsis1,[OA]

Valera V. Peremyslov2, Alexey I. Prokhnevsky2, Dror Avisar and Valerian V. Dolja*

Department of Botany and Plant Pathology (V.V.P., A.I.P., D.A., V.V.D.) and Center for Genome Research and Biocomputing (V.V.D.), Oregon State University, Corvallis, Oregon 97331

Multigene families encoding class XI myosins are conserved in higher plants, however, little information is available on specific functions of these ubiquitous molecular motors. We isolated gene knockout mutants for all 13 class XI myosins present in Arabidopsis (Arabidopsis thaliana) genome. Inactivation of 11 myosin genes resulted in no discernible phenotypes under the normal growth conditions. In contrast, the knockouts of the remaining two myosin genes, XI-2 (formerly MYA2) and XI-K, exhibited similar defects in root hair elongation suggesting that the myosin-driven motility plays a significant role in a polar tip growth. Strikingly, inactivation of each of these myosins also reduced trafficking of Golgi stacks, peroxisomes, and mitochondria in root hairs and in leaf epidermal cells. These results indicate that myosins XI-K and XI-2 play major and overlapping roles in the cell dynamics in Arabidopsis and highlight the redundant nature of myosin function in plants.

1 This work was supported in part by a grant from the National Institutes of Health (GM053190 to V.V.D.), and by a Vaadia-Binational Agricultural Research and Development Postdoctoral Fellowship (award no. F1–354–2004 to D.A.) from the U.S.-Israel Binational Agricultural Research and Development Fund. The publication was made possible in part by support from the National Institutes of Health (grant no. 1S10RR107903–01).

2 These authors contributed equally to the article.

The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (www.plantphysiol.org) is: Valerian V. Dolja (doljav{at}science.oregonstate.edu).

[OA] Open Access articles can be viewed online without a subscription.

www.plantphysiol.org/cgi/doi/10.1104/pp.107.113654

* Corresponding author; e-mail doljav{at}science.oregonstate.edu.

Received November 27, 2007; accepted December 24, 2007; published January 4, 2008.


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