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DEVELOPMENT AND HORMONE ACTION

FZR2/CCS52A1 Expression Is a Determinant of Endoreduplication and Cell Expansion in Arabidopsis^1,[W],[OA]

University of Wisconsin, Laboratory of Genetics, Madison, Wisconsin 53706 (Z.L.-R., P.H.M., C.D.D.); and State Key Laboratory of Genetic Engineering, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200433, China (Z.L.)

Endoreduplication, a modified cell cycle that allows cells to increase ploidy without subsequent cell division, is a key component of plant growth and development. In this work, we show that some, but not all, of the endoreduplication of Arabidopsis (Arabidopsis thaliana) is mediated by the expression of a WD40 gene, FIZZY-RELATED2 (FZR2). Loss-of-function alleles show reduced endoreduplication and reduced expansion in trichomes and other leaf cells. Misexpression of FZR2 is sufficient to drive ectopic or extra endoreduplication in leaves, roots, and flowers, leading to alteration of cell sizes and, sometimes, organ size and shape. Our data, which suggest that reduced cell size can be compensated by increased cell proliferation to allow normal leaf morphology, are discussed with respect to the so-called compensation mechanism of plant development.

² These authors contributed equally to the article.

³ Present address: Department of Horticulture, Room 209, 1575 Linden Dr., University of Wisconsin, Madison, WI 53706.

The author responsible for the distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (www.plantphysiol.org) is: Zachary Larson-Rabin (zmlarson{at}wisc.edu).

^[W] The online version of this article contains Web-only data.

^[OA] Open access articles can be viewed online without a subscription.

www.plantphysiol.org/cgi/doi/10.1104/pp.108.132449

^* Corresponding author; e-mail zmlarson{at}wisc.edu.

Received November 10, 2008; accepted December 5, 2008; published December 12, 2008.

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