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Plant Physiology 58:592-594 (1976)
© 1976 American Society of Plant Biologists

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Articles

Effects of Chloramphenicol on the Circadian Rhythm of Neurospora crassa1

John G. Frelinger2, Harvey Motulsky3 and Dow O. Woodward

a Department of Biological Sciences, Stanford University, Stanford, California 94305

Chloramphenicol, an inhibitor of mitochondrial protein synthesis, shortened the period length of the circadian rhythm in the Timex strain of Neurospora crassa by 2 hours. Both the L(+) threo and D(–) threo optical isomers had the same effect on the period of the rhythm, whereas only the D(–) threo isomer significantly inhibited mitochondrial protein synthesis. Tetracycline, another inhibitor of mitochondrial protein synthesis, did not change the period of the circadian rhythm. The effect of chloramphenicol on the circadian rhythm is, therefore, presumably not directly related to inhibition of mitochondrial protein synthesis, suggesting that chloramphenicol has other effects.


2 Supported in part by a grant from the Summer Undergraduate Research Program (1974) of the National Science Foundation.

Present address: Division of Biology. California Institute of Technology, Pasadena, California.

3 Present address: University of Washington School of Medicine, Seattle, Washington.

1 This research was supported in part by United States Public Health Service Grant GM100067.




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Copyright © 1976 by the American Society of Plant Biologists