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Articles

Metabolism of L-Tyrosine to 4-Hydroxybenzaldehyde and 3-Bromo-4-Hydroxybenzaldehyde by Chloroplast-containing Fractions of Odonthalia floccosa (Esp.) Falk ¹

^a Department of Biology, University of California, Los Angeles, California 90024

The biosynthesis of 4-hydroxybenzaldehyde and 3-bromo-4-hydroxybenzaldehyde from L-[U-¹⁴C]tyrosine has been demonstrated in chloroplast-containing fractions obtained by differential and isopycnic centrifugation from the marine red alga Odonthalia floccosa. Surfactant and high speed centrifugation studies indicate that the biosynthetic pathway involves a particulate enzyme system, possibly located on the thylakoid membranes. The following scheme, based upon identification of labeled ¹⁴C-intermediates, is proposed for the formation of aldehydes: L-tyrosine 4-hydroxyphenylpyruvic acid 4-hydroxyphenylacetic acid 4-hydroxymandelic acid 4-hydroxybenzaldehyde 3-bromo-4-hydroxybenzaldehyde.

¹ This research was supported by National Science Foundation Grants GB 42461 and DEB 75-19644 to D.J.C. and a National Institutes of Health Biomedical Sciences Support Grant to the University.