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L-Ascorbic Acid Biosynthesis in Ochromonas danica¹

Institute of Biological Chemistry and Program in Biochemistry and Biophysics, Washington State University, Pullman, Washington 99164

Ochromonas danica Pringsheim, a freshwater chrysomonad, converts D-glucose into L-ascorbic acid over a metabolic pathway that `inverts' the carbon chain of the sugar. In this respect, L-ascorbic acid formation resembles that found in ascorbic acid-synthesizing animals. It differs from this process in that D-galacturonate and L-galactono-1,4-lactone, rather than D-glucuronate and L-gulono-1,4-lactone, enhance production of ascorbic acid and repress the incorporation of ¹⁴C from D-[1-¹⁴C]glucose into ascorbic acid.

¹ Supported by grants from National Institutes of Health (GM-22427), National Science Foundation (PCM-7813254), and the Netherlands Organization for the Advancement of Pure Research (Z. W. O.). Scientific Paper No. 5926, Project 0266, College of Agriculture Research Center, Washington State University, Pullman, WA 99164.

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