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L-Canavanine Metabolism in Jack Bean, Canavalia ensiformis (L.) DC. (Leguminosae) ¹

T. H. Morgan School of Biological Sciences, University of Kentucky, Lexington, Kentucky 40506

L-Canavanine, a highly toxic arginine antimetabolite, is the principal nonprotein amino acid of many leguminous plants. Labeled-precursor feeding studies, conducted primarily with [¹⁴C]carbamoyl phosphate, and utilization of the seedlings of jack bean, Canavalia ensiformis (L.) DC. (Leguminosae), have provided evidence for L-canavanine biosynthesis from L-canaline via O-ureido-L-homoserine. This reaction pathway appears to constitute an important in vivo route of canavanine production. Canavanine cleavage to canaline may represent a degradative phase of canavanine metabolism distinct from the anabolic reactions described above. Thus, while these reactions of canavanine metabolism bear analogy to the mammalian Krebs-Henseleit ornithine-urea cycle, no evidence has been obtained at present for the reutilization of canaline in ureidohomoserine formation.

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