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Plant Physiology 69:1113-1115 (1982)
© 1982 American Society of Plant Biologists

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Articles

Inhibition of Cyanide-Resistant Respiration in Pea Cotyledon Mitochondria by Chloroquine 1

Terrance W. James and Mary S. Spencer

Department of Plant Science, University of Alberta, Edmonton, Alberta, Canada, T6G 2P5

The action on mitochondrial respiration of a ubiquinone analog, chloroquine, has been studied using purified mitochondria from the cotyledons of germinating peas (Pisum sativum L. var. Homesteader). Chloroquine at 3 millimolar did not inhibit malate or succinate oxidation at pH 7.2, but it did inhibit malate (but not succinate) oxidation at pH 8.2. Cyanide-resistant respiration was also inhibited.

The implications of these experiments on the role of ubiquinone in the cyanide-resistant respiratory pathway and on the location of the alternate oxidase are discussed.

1 Supported by the Natural Sciences and Engineering Research of Canada in the form of a grant (to M. S. S.) and a postgraduate scholarship (to T. W. J.).






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Copyright © 1982 by the American Society of Plant Biologists