Plant Physiol.
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Plant Physiology 76:972-975 (1984)
© 1984 American Society of Plant Biologists

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Articles

Isolation and Characterization of Swainsonine from Texas Locoweed (Astragalus emoryanus) 1

Dawn Davis, Patricia Schwarz, Tony Hernandez, Mike Mitchell, Barton Warnock and Alan D. Elbein

Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas 78284, Division of Earth Sciences, University of Texas, San Antonio, Texas 78284, Department of Biology, Sul Ross State University, Alpine, Texas 79830

Swainsonine (1,2,8-trihydroxyoctahydroindolizine) was isolated from locoweed (Astragalus emoryanus) that grows in Texas. Using a biological assay as a measure of activity and purity, a relatively straightforward purification of the compound is described. The purified material was a potent inhibitor of jack bean {alpha}-mannosidase and also of glycoprotein processing. The positive ion electron impact mass spectra of this compound was identical to that of authentic swainsonine. Nuclear magnetic resonance analysis also confirmed that the material was swainsonine.

1 Supported by a grant from the National Institutes of Health (AM 21800) and from the Robert A. Welch Foundation.






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Copyright © 1984 by the American Society of Plant Biologists