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Membranes and Bioenergetics

Inhibition of Adenosine Triphosphatase Activity from a Plasma Membrane Fraction of Acer pseudoplatanus Cells by Carbanilate Derivatives ^1,2

Laboratoire des Herbicides et Autres Produits Phytosanitaires, Institut National de la Recherche Agronomique, BV 1540, 21034 Dijon Cedex, France, Laboratoire de Chimie Organique et Biologique, E.N.S.A., 145 av de Muret, 31076 Toulouse Cedex, France

Thirty-one carbanilate derivatives were assayed for their capabilities to inhibit the ATPase activity of a plasma membrane fraction from Acer pseudoplatanus cells. At a concentration of 100 micromolar, nine compounds strongly inhibited the ATPase activity, with I₅₀ ranging from 14.5 micromolar to 35 micromolar. These molecules were also inhibitory to plasma membrane ATPases of other origins: plant (maize shoot), yeast (Schizosaccharomyces pombe), and animal (dog kidney). The most efficient molecule appeared to be 2,2,2-trichloroethyl 3,4-dichlorocarbanilate.

² All requests about ethyl carbanilate derivatives should be sent to Jean-Pierre Blein or René Scalla.