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Plant Physiology 85:1-3 (1987) © 1987 American Society of Plant Biologists The Use of Cytotoxic Plant Lectins in Cancer TherapyDepartment of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom As part of their defense mechanism against herbivores or phytophagous insects, many plant tissues contain lectins. Some of these lectins are potent toxins which kill animal cells by arresting protein synthesis. An attractive strategy for developing specifically cytotoxic chemotherapeutic agents is to link cell type-specific monoclonal antibodies to potent toxins. The plant protein ricin has emerged as the toxin of choice for such constructs.
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