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Metabolism and Enzymology

Fructose 2,6-Bisphosphate Inhibition of Phosphoglucomutase ¹

Department of Botany and Plant Sciences, University of California, Riverside, California 92521, Department of Biochemistry, University of Georgia, Athens, Georgia 30602

Fructose 2,6-bisphosphate inhibits phosphoglucomutase noncompetitively with respect to the cofactor glucose 1,6-bisphosphate. Previous studies from our laboratory had shown that phosphoglucomutase was activated by fructose 2,6-bisphosphate in the absence of added glucose 1,6-bisphosphate. The fructose 2,6-bisphosphate activation previously reported was due to the presence of glucose 1,6-bisphosphate in the commercial preparation of fructose 2,6-bisphosphate.

¹ This research was supported in part by a Chancellor's Patent Fund Award to C. M. G. and by the California Agricultural Experiment Station.