Plant Physiol. Journal of Pharmacology and Experimental Therapeutics
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First published online February 24, 2002; 10.1104/pp.010685

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Plant Physiol, March 2002, Vol. 128, pp. 951-961

Snakin-2, an Antimicrobial Peptide from Potato Whose Gene Is Locally Induced by Wounding and Responds to Pathogen Infection1

Marta Berrocal-Lobo, Ana Segura,2 Manuel Moreno, Gemma López, Francisco García-Olmedo, and Antonio Molina*

Laboratorio de Bioquímica y Biología Molecular, Departamento de Biotecnología-Universidad Politecnica Madrid, Escuela Tecnica Superior Ingenieros Agrónomos, E-28040 Madrid, Spain

The peptide snakin-2 (StSN2) has been isolated from potato (Solanum tuberosum cv Jaerla) tubers and found to be active (EC50 = 1-20 µM) against fungal and bacterial plant pathogens. It causes a rapid aggregation of both Gram-positive and Gram-negative bacteria. The corresponding StSN2 cDNA encodes a signal sequence followed by a 15-residue acidic sequence that precedes the mature StSN2 peptide, which is basic (isoelectric point = 9.16) and 66 amino acid residues long (molecular weight of 7,025). The StSN2 gene is developmentally expressed in tubers, stems, flowers, shoot apex, and leaves, but not in roots, or stolons, and is locally up-regulated by wounding and by abscisic acid treatment. Expression of this gene is also up-regulated after infection of potato tubers with the compatible fungus Botritys cinerea and down-regulated by the virulent bacteria Ralstonia solanacearum and Erwinia chrysanthemi. These observations are congruent with the hypothesis that the StSN2 is a component of both constitutive and inducible defense barriers.

1 This work was supported by the Dirección General de Investigacion Cientifica y Technica (grant no. PB92-0325 to F.G.-O.), by the Comunidad de Madrid (grant no. 07B/0002/1999 to A.M.), by the Ministerio de Ciencia y Tecnología from Spain (grant no. BIO2000-1308 to A.M), and by the European Project BIOCT97-2120 (DGXII-SSMI to M.B.-L.).

2 Present address: Estación Experimental del Zaidín, Consejo Superior de Investigaciones Científicas, Granada, Spain.

* Corresponding author; e-mail molina{at}bit.etsia.upm.es; fax 34-91-3365757.

© 2002 American Society of Plant Physiologists


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