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First published online June 14, 2002; 10.1104/pp.010954

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Plant Physiol, July 2002, Vol. 129, pp. 1076-1085

The Barley MLO Modulator of Defense and Cell Death Is Responsive to Biotic and Abiotic Stress Stimuli1

Pietro Piffanelli, Fasong Zhou, Catarina Casais, James Orme, Birgit Jarosch, Ulrich Schaffrath, Nicholas C. Collins, Ralph Panstruga, and Paul Schulze-Lefert*

The Sainsbury Laboratory, John Innes Centre, NR4 7UH Norwich, United Kingdom (P.P., F.Z., C.C., J.O., N.C.C.); Rheinisch-Westfälische Technische Hochschule Aachen, Institut für Biologie III, D-52074 Aachen, Germany (B.J., U.S.); and Max-Planck-Institut für Züchtungsforschung, Department of Plant Microbe Interactions, D-50829 Köln, Germany (R.P., P.S.-L.)

Lack of the barley (Hordeum vulgare) seven-transmembrane domain MLO protein confers resistance against the fungal pathogen Blumeria graminis f. sp. hordei (Bgh). To broaden the basis for MLO structure/function studies, we sequenced additional mlo resistance alleles, two of which confer only partial resistance. Wild-type MLO dampens the cell wall-restricted hydrogen peroxide burst at points of attempted fungal penetration of the epidermal cell wall, and in subtending mesophyll cells, it suppresses a second oxidative burst and cell death. Although the Bgh-induced cell death in mlo plants is spatially and temporally separated from resistance, we show that the two processes are linked. Uninoculated mutant mlo plants exhibit spontaneous mesophyll cell death that appears to be part of accelerated leaf senescence. Mlo transcript abundance increases in response to Bgh, rice (Oryza sativa) blast, wounding, paraquat treatment, a wheat powdery mildew-derived carbohydrate elicitor, and during leaf senescence. This suggests a broad involvement of Mlo in cell death protection and in responses to biotic and abiotic stresses.

1 This work was supported by the Gatsby Charitable Organization and the Max-Planck Society (grants to P.S.-L.), by the Biotechnology and Biological Science Research Council (research grant no. 83/P09868 to P.P. and C.C.), and by the European Union-funded European Gramineae Mapping Project consortium (to F.Z.).

* Corresponding author; e-mail schlef{at}mpiz-koeln.mpg.de; fax 49-221-5062-313.

© 2002 American Society of Plant Physiologists


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