OPEN ACCESS ARTICLE

This Article Free via Open Access: OA OA Full Text Full Text (PDF) Supplemental Data OA All Versions of this Article: 144/1/173    most recent pp.106.093575v1 Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Web of Science (13) Citing Articles via Google Scholar Google Scholar Articles by Petricka, J. J. Articles by Nelson, T. M. Search for Related Content PubMed PubMed Citation Articles by Petricka, J. J. Articles by Nelson, T. M. Agricola Articles by Petricka, J. J. Articles by Nelson, T. M.

DEVELOPMENT AND HORMONE ACTION

Arabidopsis Nucleolin Affects Plant Development and Patterning^1,[W],[OA]

Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520–8104

Nucleolin is a major nucleolar protein implicated in many aspects of ribosomal biogenesis, including early events such as processing of the large 35S preribosomal RNA. We found that the Arabidopsis (Arabidopsis thaliana) parallel1 (parl1) mutant, originally identified by its aberrant leaf venation, corresponds to the Arabidopsis nucleolin gene. parl1 mutants display parallel leaf venation, aberrant localization of the provascular marker Athb8:-glucuronidase, the auxin-sensitive reporter DR5:-glucuronidase, and auxin-dependent growth defects. PARL1 is highly similar to the yeast (Saccharomyces cerevisiae) nucleolin NUCLEAR SIGNAL RECOGNITION 1 (NSR1) multifunctional protein; the Arabidopsis PARL1 gene can rescue growth defects of yeast nsr1 null mutants. This suggests that PARL1 protein may have roles similar to those of the yeast nucleolin in nuclear signal recognition, ribosomal processing, and ribosomal subunit accumulation. Based on the range of auxin-related defects in parl1 mutants, we propose that auxin-dependent organ growth and patterning is highly sensitive to the efficiency of nucleolin-dependent ribosomal processing.

The author responsible for distribution of materials integral to the findings presented in this article in accordance with the policy described in the Instructions for Authors (www.plantphysiol.org) is: Timothy Mark Nelson (timothy.nelson{at}yale.edu).

^[W] The online version of this article contains Web-only data.

^[OA] Open Access articles can be viewed online without a subscription.

www.plantphysiol.org/cgi/doi/10.1104/pp.106.093575

^* Corresponding author; e-mail timothy.nelson{at}yale.edu; fax 203–432–3854.

Received November 27, 2006; accepted March 13, 2007; published March 16, 2007.

This article has been cited by other articles:

				T. J. Donner, I. Sherr, and E. Scarpella Regulation of preprocambial cell state acquisition by auxin signaling in Arabidopsis leaves Development, October 1, 2009; 136(19): 3235 - 3246. [Abstract] [Full Text] [PDF]

				R. F. Degenhardt and P. C. Bonham-Smith Arabidopsis Ribosomal Proteins RPL23aA and RPL23aB Are Differentially Targeted to the Nucleolus and Are Disparately Required for Normal Development Plant Physiology, May 1, 2008; 147(1): 128 - 142. [Abstract] [Full Text] [PDF]