Plant Physiology Preview
Published on June 14, 2002; 10.1104/pp.010954
Received October 18, 2001
Returned for revision February 19, 2002
Accepted March 13, 2002
The Barley MLO Modulator of Defense and Cell Death Is Responsive
to Biotic and Abiotic Stress Stimuli
Pietro Piffanelli , Fasong Zhou , Catarina Casais , James Orme , Birgit Jarosch , Ulrich Schaffrath , Nicholas C. Collins , Ralph Panstruga , and Paul Schulze-Lefert *
The Sainsbury Laboratory, John Innes Centre, NR4 7UH Norwich, United Kingdom (P.P., F.Z., C.C., J.O., N.C.C.); Rheinisch-Westfälische Technische Hochschule Aachen, Institut für Biologie III, D--52074 Aachen, Germany (B.J., U.S.); and Max-Planck-Institut für Züchtungsforschung, Department of Plant Microbe Interactions, D--50829 Köln, Germany (R.P., P.S.-L.)
* Corresponding author; email: schlef{at}mpiz-koeln.mpg.de.
Lack of the barley (Hordeum vulgare) seven-transmembrane domain MLO protein confers resistance against the fungal pathogen Blumeria graminis f. sp. hordei (Bgh). To broaden the basis for MLO structure/function studies, we sequenced additional mlo resistance alleles, two of which confer only partial resistance. Wild-type MLO dampens the cell wall-restricted hydrogen peroxide burst at points of attempted fungal penetration of the epidermal cell wall, and in subtending mesophyll cells, it suppresses a second oxidative burst and cell death. Although the Bgh-induced cell death in mlo plants is spatially and temporally separated from resistance, we show that the two processes are linked. Uninoculated mutant mlo plants exhibit spontaneous mesophyll cell death that appears to be part of accelerated leaf senescence. Mlo transcript abundance increases in response to Bgh, rice (Oryza sativa) blast, wounding, paraquat treatment, a wheat powdery mildew-derived carbohydrate elicitor, and during leaf senescence. This suggests a broad involvement of Mlo in cell death protection and in responses to biotic and abiotic stresses.
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