Plant Physiology Preview
Published on February 25, 2005; 10.1104/pp.104.048751
Received June 25, 2004
Returned for revision December 24, 2004
Accepted December 28, 2004
Crystal Structures of Alfalfa Caffeoyl Coenzyme A 3-O-Methyltransferase
Jean-Luc Ferrer , Chloe Zubieta , Richard A. Dixon , and Joseph P. Noel *
Laboratoire de Cristallographie et Cristallogenèse des Protéines, Institut de Biologie Structurale, 38027 Grenoble cedex 1, France
Jack Skirball Chemical Biology and Proteomics Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92037
Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401
* Corresponding author; email: noel{at}salk.edu.
Caffeoyl coenzyme A 3-O-methyltransferases (CCoAOMTs) are S-adenosyl-L-methionine-dependent O-methyltransferases (OMTs) involved in lignin biosynthesis. Plant CCoAOMTs belong to a distinct family of OMTs, more closely related to the mammalian catechol OMTs than to other plant OMTs. The crystal structure of alfalfa (Medicago sativa) CCoAOMT in complex with the reaction products S-adenosine-L-homocysteine and feruloyl/sinapoyl CoAs presented here belong to a structurally and mechanistically distinct family of plant small molecule OMTs. These structures provide a new understanding of the substrate preferences and the catalytic mechanism accompanying CCoAOMT-mediated O-methylation of CoA-linked phenylpropanoid substrates.
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