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Published on October 13, 2006; 10.1104/pp.106.088344

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Received August 15, 2006
Accepted September 27, 2006

Developmentally Controlled Farnesylation Modulates AtNAP1;1 Function in Cell Proliferation and Cell Expansion during Arabidopsis Leaf Development

Arnaud Galichet and Wilhelm Gruissem *

Institute of Plant Sciences, ETH Zürich, Universitätstrasse 2, 8092 Zürich, Switzerland.

* Corresponding author; email: wgruissem{at}ethz.ch.

In multicellular organisms, organogenesis requires tight control and coordination of cell proliferation, cell expansion and cell differentiation. We have identified AtNAP1;1 (Arabidopsis thaliana Nucleosome Assembly Protein 1) as a component of a regulatory mechanism that connects cell proliferation to cell growth and expansion during Arabidopsis leaf development. Molecular, biochemical and kinetic studies of AtNAP1;1 gain- or loss-of-function mutants indicate that AtNAP1;1 promotes cell proliferation or cell expansion in a developmental context and as a function of the farnesylation status of the protein. AtNAP1;1 was farnesylated and localized to the nucleus during the cell proliferation phase of leaf development when it promotes cell division. Later in leaf development non-farnesylated AtNAP1;1 accumulates in the cytoplasm when it promotes cell expansion. Ectopic expression of non-farnesylated AtNAP1;1, which localized to the cytoplasm, disrupts this developmental program by promoting unscheduled cell expansion during the proliferation phase.




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