Plant Physiology Preview
Published on February 9, 2007; 10.1104/pp.107.095521
OPEN ACCESS ARTICLE
Received January 5, 2007
Accepted January 31, 2007
Involvement of the Histone Acetyltransferase AtHAC1 in the Regulation of Flowering Time via Repression of FLC in Arabidopsis
WeiWei Deng , ChunYan Liu , YanXi Pei , Xian Deng , LiFang Niu , and XiaoFeng Cao *
State Key Laboratory of Plant Genomics and Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China 100101; Graduate School, Chinese Academy of Sciences, Beijing, China, 100039 and College of Life Science and Technology, Shanxi University, Taiyuan, China, 030006
* Corresponding author; email: xfcao{at}genetics.ac.cn.
Histone acetylation is an important post-translational modification correlated with gene activation. In Arabidopsis, the histone acetyltransferase AtHAC1 is homologous to animal p300/CBP (CREB-binding protein) proteins, which are the main histone acetyltransferases participating in many physiological processes, including proliferation, differentiation and apoptosis (Goodman and Smolik, 2000; Shikama et al., 2000). The functions of p300/CBP in animals are well characterized, whereas little is known about the roles of AtHAC1 in developmental control in Arabidopsis. Lesions in AtHAC1 caused pleiotropic developmental defects, including delayed flowering, a shortened primary root and partially reduced fertility. Analysis of the molecular basis of late-flowering in hac1 mutants showed that the hac1 plants respond normally to day-length, gibberellin acid (GA) treatment and vernalization. Furthermore, the expression level of the flowering repressor FLOWERING LOCUS C (FLC) is increased in hac1 mutants, indicating that the late-flowering phenotype of hac1 mutants is mediated by FLC. Since histone acetylation is usually associated with the activation of gene expression, histone modifications of FLC chromatin are not affected by mutations in HAC1 and expression levels of all known autonomous pathway genes are unchanged in hac1 plants, we propose that HAC1 affects flowering time by epigenetic modification of factors upstream of FLC.
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