Plant Physiol.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Plant Physiology Preview
Published on May 18, 2007; 10.1104/pp.107.098079

OPEN ACCESS ARTICLE
This Article
Free via Open Access: OA
Right arrow Full Text (Plant Physiology Preview (PDF))
Right arrowOA All Versions of this Article:
144/3/1531    most recent
pp.107.098079v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Feng, H.
Right arrow Articles by Zuo, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Feng, H.
Right arrow Articles by Zuo, J.
Agricola
Right arrow Articles by Feng, H.
Right arrow Articles by Zuo, J.

Received February 14, 2007
Accepted May 16, 2007

Functional Characterization of the Arabidopsis Eukaryotic Translation Initiation Factor 5A-2 (eIF-5A-2) that plays a Crucial Role in Plant Growth and Development by Regulating Cell Division, Cell Growth and Cell Death

Haizhong Feng , Qingguo Chen , Jian Feng , Jian Zhang , Xiaohui Yang , and Jianru Zuo *

State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Datun Road, Beijing 100101, China

* Corresponding author; email: jrzuo{at}genetics.ac.cn.

The eukaryotic translation initiation factor 5A (eIF-5A) is a highly conserved protein found in all eukaryotic organisms. Although originally identified as a translation initiation factor, recent studies in mammalian and yeast cells suggest that eIF-5A is mainly involved in RNA metabolism and trafficking, thereby regulating cell proliferation, cell growth and programmed cell death (PCD). In higher plants, the physiological function of eIF-5A remains largely unknown. Here, we report the identification and characterization of an Arabidopsis mutant fumonisin B1-resistant12 (fbr12). The fbr12 mutant shows an anti-apoptotic phenotype and has reduced dark-induced leaf senescence. Moreover, fbr12 displays severe defects in plant growth and development. The fbr12 mutant plant is extreme dwarf with substantially reduced size and number of all adult organs. During reproductive development, fbr12 causes abnormal development of floral organs and defective sporogenesis, leading to the abortion of both female and male germline cells. Microscopic studies revealed that these developmental defects are associated with abnormal cell division and cell growth. Genetic and molecular analyses indicated that FBR12 encodes a putative eIF-5A-2 protein. When expressed in a yeast mutant strain carrying a mutation in the eIF-5A gene, an FBR12 cDNA is able to rescue the lethal phenotype of the yeast mutant, indicating that FBR12 is a functional eIF-5A. We propose that FBR12/eIF-5A-2 is fundamental for plant growth and development by regulating cell division, cell growth and cell death.




This article has been cited by other articles:


Home page
 J Exp BotHome page
G. Barel and I. Ginzberg
Potato skin proteome is enriched with plant defence components
J. Exp. Bot., September 1, 2008; 59(12): 3347 - 3357.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
M. T. Hopkins, Y. Lampi, T.-W. Wang, Z. Liu, and J. E. Thompson
Eukaryotic Translation Initiation Factor 5A Is Involved in Pathogen-Induced Cell Death and Development of Disease Symptoms in Arabidopsis
Plant Physiology, September 1, 2008; 148(1): 479 - 489.
[Abstract] [Full Text] [PDF]

Home page
 Plant Physiol.Home page
C. Teng, H. Dong, L. Shi, Y. Deng, J. Mu, J. Zhang, X. Yang, and J. Zuo
Serine Palmitoyltransferase, a Key Enzyme for de Novo Synthesis of Sphingolipids, Is Essential for Male Gametophyte Development in Arabidopsis
Plant Physiology, March 1, 2008; 146(3): 1322 - 1332.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
ASPB Publications PLANT PHYSIOLOGY® THE PLANT CELL
Copyright © 2007 by the American Society of Plant Biologists