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Published on July 13, 2007; 10.1104/pp.107.100800

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Received April 9, 2007
Accepted July 5, 2007

The Arabidopsis BAP1 and BAP2 Genes Are General Inhibitors of Programmed Cell Death

Huijun Yang , Shuhua Yang , Yongqing Li , and Jian Hua *

Department of Plant Biology, Cornell University, Ithaca, NY 14853

* Corresponding author; email: jh299{at}cornell.edu.

Here we identify the BAP1 and BAP2 genes of Arabidopsis thaliana as general inhibitors of programmed cell death across the kingdoms. These two homologous genes encode small proteins containing a calcium-dependent phospholipid binding C2 domain. BAP1 and its functional partner BON1 have been shown to negatively regulate defense responses and a disease resistance gene SNC1. Genetic studies here reveal an overlapping function of the BAP1 and BAP2 genes in cell death control. The loss of BAP2 function induces accelerated hypersensitive responses but does not compromise plant growth or confer enhanced resistance to virulent bacterial or oomycete pathogens. The loss of both BAP1 and BAP2 confers seedling lethality mediated by PAD4 and EDS1, two regulators of cell death and defense responses. Overexpression of BAP1 or BAP2 with their partner BON1 inhibits programmed cell death induced by pathogens, the proapototic gene BAX and superoxide-generating paraquat in Arabidopsis or Nicotiana benthamiana. Moreover, expressing BAP1 or BAP2 in yeast alleviates cell death induced by hydrogen peroxide. Thus, the BAP genes function as general negative regulators of programmed cell death induced by biotic and abiotic stimuli including reactive oxygen species. The dual roles of BAP and BON genes in repressing defense responses mediated by disease resistance genes and in inhibiting general programmed cell death has implications in understanding the evolution of plant innate immunity.




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