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Published on February 27, 2008; 10.1104/pp.107.111260

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Received October 20, 2007
Accepted February 20, 2008

Arabidopsis PPR40 connects abiotic stress responses to mitochondrial electron transport

Laura Zsigmond , Gabor Rigo , Andras Szarka , Gyongyi Szekely , Krisztina Otvos , Zsuzsanna Darula , Katalin F. Medzihradszky , Csaba Koncz , Zsuzsa Koncz , and Laszlo Szabados *

Institute of Plant Biology, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary; Department of Applied Biotechnology and Food Science, Laboratory of Biochemistry and Molecular Biology, Budapest University of Technology and Economics, Budapest, Hungary; Pathobiochemistry Research Group of Hungarian Academy of Sciences and Semmelweis University Budapest, Hungary; Proteomics Research Group, Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA 94143-0446, USA; Max-Planck-Institut fur Zuchtungsforschung, D-50829 Cologne, Germany

* Corresponding author; email: szabados{at}brc.hu.

Oxidative respiration produces ATP through the mitochondrial electron transport system controlling the energy supply of plant cells. Here we describe a mitochondrial pentatricopeptide (PPR) domain protein, PPR40, which provides a signalling link between mitochondrial electron transport and regulation of stress and hormonal responses in Arabidopsis thaliana. Insertion mutations inactivating PPR40 result in semi-dwarf growth habit and enhanced sensitivity to salt, ABA and oxidative stress. Genetic complementation by overexpression of PPR40 cDNA restores the ppr40 mutant phenotype to wild type. The PPR40 protein is localized in the mitochondria and found in association with Complex III of the electron transport system. In the ppr40-1 mutant the electron transport through Complex III is strongly reduced, while Complex IV is functional, indicating that PPR40 is important for the ubiqinol-cytochrome c oxidoreductase activity of Complex III. Enhanced stress sensitivity of the ppr40-1 mutant is accompanied by accumulation of reactive oxygen species, enhanced lipid peroxidation, higher SOD activity and altered activation of several stress responsive genes including the alternative oxidase AOX1d. These results suggest a close link between regulation of oxidative respiration and environmental adaptation in Arabidopsis.




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