GENEVESTIGATOR. Arabidopsis Microarray Database and Analysis Toolbox

doi:10.1104/pp.104.046367

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GENEVESTIGATOR. Arabidopsis Microarray Database and Analysis Toolbox¹^,[w]

Philip Zimmermann², Matthias Hirsch-Hoffmann², Lars Hennig and Wilhelm Gruissem^*

Institute of Plant Sciences, Swiss Federal Institute of Technology and Zurich-Basel Plant Science Center, ETH Center, CH–8092 Zurich, Switzerland (P.Z., M.H.-H., L.H., W.G.); and Functional and Genomics Center Zurich, UNI Irchel, Y32 H52, CH–8057 Zurich, Switzerland (W.G.)

High-throughput gene expression analysis has become a frequentand powerful research tool in biology. At present, however,few software applications have been developed for biologiststo query large microarray gene expression databases using aWeb-browser interface. We present GENEVESTIGATOR, a databaseand Web-browser data mining interface for Affymetrix GeneChipdata. Users can query the database to retrieve the expressionpatterns of individual genes throughout chosen environmentalconditions, growth stages, or organs. Reversely, mining toolsallow users to identify genes specifically expressed duringselected stresses, growth stages, or in particular organs. UsingGENEVESTIGATOR, the gene expression profiles of more than 22,000Arabidopsis genes can be obtained, including those of 10,600currently uncharacterized genes. The objective of this softwareapplication is to direct gene functional discovery and designof new experiments by providing plant biologists with contextualinformation on the expression of genes. The database and analysistoolbox is available as a community resource at https://www.genevestigator.ethz.ch.

¹ This work was supported by ETH, Strategic Excellence Project2–74213–02/TH–8/02–2, and by the FunctionalGenomics Center Zurich.

² These authors contributed equally to the paper.

^[w] The online version of this article contains Web-only data.

www.plantphysiol.org/cgi/doi/10.1104/pp.104.046367.

^{^*} Corresponding author; e-mail wilhelm.gruissem{at}ipw.biol.ethz.ch; fax 41–1–632–10–79.

Received May 14, 2004; returned for revision July 12, 2004; accepted July 16, 2004.

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GENEVESTIGATOR. Arabidopsis Microarray Database and Analysis Toolbox1,[w]

GENEVESTIGATOR. Arabidopsis Microarray Database and Analysis Toolbox¹^,[w]