Article Figures & Data
Figures
- Figure 1.
Schematic of the central carbon metabolism of Synechococcus 2973. Reactions exclusive to the core model (Abernathy et al., 2017) and imSyu593 are highlighted in red and green, respectively. *, Metabolites whose labeling data were fitted in this study. 2pglyc, 2-Phosphoglycolate; 6PGDH, 6-phosphogluconate dehydrogenase; acetyl-p, acetyl phosphate; ACON, aconitase; akg, α-ketoglutarate; CS, citrate synthase; dhap, dihydroxyacetone phosphate; ENO, enolase; FBA, Fru bisphosphate aldolase; fbp, Fru bisphosphate; FDH, fumarate dehydrogenase; fum, fumarate; g1p, Glc-1-P; G6PDH, Glc-6-P dehydrogenase; gap, glyceraldehyde-3-phosphate; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GDC, Gly decarboxylase; GK, glycerate kinase; glx, glyoxalate; HPR, hydroxypyruvate reductase; ICL, isocitrate lyase; IDH, isocitrate dehydrogenase; MS, malate synthase; oaa, oxaloacetate; OGDC, 2-oxoglutarate decarboxylase; PGI, phosphoglucose mutase; PGK, phosphoglycerate kinase, PGLCM, phosphoglucomutase; PGLYM, phosphoglycerate mutase; PK, pyruvate kinase; PPC, phosphoenolpyruvate carboxylase; PPI, pentose phosphate isomerase; pyr, pyruvate; ru5p, ribulose-5-phosphate; RU5PE, ribulose-5-phosphate epimerase; rubp, ribulose-1,5-bisphosphate; SDH, succinate dehydrogenase; SGAT, Ser-glyoxylate aminotransferase; SHMT, Ser-hydroxymethyl transferase; SSDH, succinic semialdehyde dehydrogenase; TKT, transketolase; TPI, triosephosphate isomerase.
- Figure 2.
Comparison of variance-weighted SSR obtained, in the case of Synechococcus 2973, using the core model and imSyu593 for the various metabolite fragments. Green bars correspond to the core model, and brown bars correspond to imsyu593. Lower SSR indicates a better recapitulation of the labeling dynamics for the corresponding fragment. *Fragments for which the difference in SSR is greater than 25.
- Figure 3.
Comparison of the flux ranges (95% confidence interval) for relevant reactions obtained using the core model (Abernathy et al., 2017) and imSyu593 under photoautotrophic conditions. Green bars correspond to the core model, and brown bars correspond to imsyu593. The left end of each bar indicates the lower bound, and the right end of each bar indicates the upper bound. The fluxes are normalized to a carbon uptake of 100 mmol g−1 dry weight (DW) h−1. See Figure 1 for abbreviations and details of individual reactions.
- Figure 4.
Comparison of the normalized flux ranges (95% confidence interval) of selected reactions between Synechococcus 2973 and Synechocystis 6803 (Gopalakrishnan et al., 2018) under the photoautotrophic conditions. Brown bars correspond to Synechococcus 2973, and blue bars correspond to Synechocystis 6803. The left end of each bar indicates the lower bound, and the right end of each bar indicates the upper bound. The fluxes are normalized to a bicarbonate uptake of 100 mmol g−1 dry weight (DW) h−1. See Figure 1 for abbreviations and details on individual reactions.
Additional Files
Supplemental Data
Supplemental Table and Figures
Files in this Data Supplement:
- Supplemental Data - Supplemental Figure
- Supplemental Data - Supplemental Tables 1-7
