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The distinct roles of class I and II RPD3-like histone deacetylases in salinity stress response

Minoru Ueda, Akihiro Matsui, Maho Tanaka, Tomoe Nakamura, Takahiro Abe, Kaori Sako, Taku Sasaki, Jong-Myong Kim, Akihiro Ito, Norikazu Nishino, Hiroaki Shimada, Minoru Yoshida, Motoaki Seki
Minoru Ueda
Plant Genomic Network Research Team, RIKEN Center for Sustainable Resource Science CITY: Yokohama POSTAL_CODE: 230-0045 Japan [JP]
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Akihiro Matsui
RIKEN CSRS CITY: Yokohama STATE: Kanagawa POSTAL_CODE: 2300047 Japan [JP]
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Maho Tanaka
Plant Genomic Network Research Team, RIKEN Center for Sustainable Resource Science CITY: 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama STATE: Kanagawa 230-0045 Japan [JP]
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Tomoe Nakamura
Tokyo University of Science CITY: Katsushika Japan [JP]
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Takahiro Abe
Plant Genomic Network Research Team, RIKEN Center for Sustainable Resource Science CITY: Yokohama Japan [JP]
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Kaori Sako
Plant Genomic Network Research Team, RIKEN Center for Sustainable Resource Science CITY: Yokohama Japan [JP]
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Taku Sasaki
Plant Genomic Network Research Team, RIKEN Center for Sustainable Resource Science CITY: Yokohama Japan [JP]
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Jong-Myong Kim
Plant Genomic Network Research Team, RIKEN Center for Sustainable Resource Science CITY: 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama STATE: Kanagawa 230-0045 Japan [JP]
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Akihiro Ito
Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science CITY: Wako Japan [JP]
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Norikazu Nishino
Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science CITY: Wako Japan [JP]
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Hiroaki Shimada
2Department of Biological Science & Technology, Tokyo University of Science CITY: Katsushika Japan [JP]
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Minoru Yoshida
Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science CITY: Wako Japan [JP]
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Motoaki Seki
Plant Genomic Network Research Team, RIKEN Center for Sustainable Resource Science CITY: Yokohama POSTAL_CODE: 230-0045 Japan [JP]
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  • For correspondence: motoaki.seki@riken.jp

Published October 2017. DOI: https://doi.org/10.1104/pp.17.01332

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  • {copyright, serif} 2017 American Society of Plant Biologists. All rights reserved.

Abstract

Histone acetylation is an essential process in the epigenetic regulation of diverse biological processes including environmental stress responses in plants. Previously, our research group identified a histone deacetylase (HDAC) inhibitor (HDI) that confers salt tolerance in Arabidopsis. In the present study, we demonstrate that class I HDAC (HDA19) and class II HDACs (HDA5/14/15/18) control responses to salt stress through different pathways. The screening of 12 different selective HDIs indicated that seven newly reported HDIs enhance salt tolerance. Genetic analysis, based on a pharmacological study, identified which HDACs function in salinity stress tolerance. In the wild-type Col-0 background, hda19 plants exhibit tolerance to high salinity stress, while hda5/14/15/18 plants exhibit hyper-sensitivity to salt stress. Transcriptome analysis revealed that the effect of HDA19-deficiency on the response to salinity stress is distinct from that of HDA5/14/15/18-deficiencies. In hda19 plants, the expression levels of stress-tolerance related genes; late embryogenesis abundant (LEA) proteins which prevent protein aggregation, and positive regulators such as ABI5 and NAC019 in ABA signaling, were strongly induced, relative to the wild-type. Neither of these elements were up-regulated in the hda5/14/15/18 plants. The mutagenesis of HDA19 by genome editing in the hda5/14/15/18 plants enhanced salt tolerance, suggesting that suppression of HDA19 masks the phenotype caused by that of class II HDACs in salinity stress response. Collectively, our results demonstrate that HDIs which inhibit class I HDACs allow the rescue of plants from salinity stress regardless of their selectivity, and provide insight into the hierarchal regulation of environmental stress responses through HDAC isoforms.

  • Received September 15, 2017.
  • Accepted October 6, 2017.

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Distinct roles of HDACs in salt stress response
Minoru Ueda, Akihiro Matsui, Maho Tanaka, Tomoe Nakamura, Takahiro Abe, Kaori Sako, Taku Sasaki, Jong-Myong Kim, Akihiro Ito, Norikazu Nishino, Hiroaki Shimada, Minoru Yoshida, Motoaki Seki
Plant Physiology Oct 2017, pp.01332.2017; DOI: 10.1104/pp.17.01332

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Distinct roles of HDACs in salt stress response
Minoru Ueda, Akihiro Matsui, Maho Tanaka, Tomoe Nakamura, Takahiro Abe, Kaori Sako, Taku Sasaki, Jong-Myong Kim, Akihiro Ito, Norikazu Nishino, Hiroaki Shimada, Minoru Yoshida, Motoaki Seki
Plant Physiology Oct 2017, pp.01332.2017; DOI: 10.1104/pp.17.01332
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Plant Physiology: 176 (4)
Plant Physiology
Vol. 176, Issue 4
Apr 2018
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