Table I.

Examples of PA-binding proteins identified in plants, animals, and yeast

PA-Binding ProteinProtein FunctionReference
From plants:
ABI1Protein phosphatase 2C likeZhang et al. (2004)
AtPDK13′-Phopshoinositide-dependent kinase 1Anthony et al. (2004)
PEPCPhosphoenolpyruvate carboxylaseTesterink et al. (2004)a
From yeast:
Opi1pSoluble transcriptional repressorLoewen et al. (2004)
From animals:
mTORMammalian target of rapamycinFang et al. (2001)
Raf1MAP kinase kinase kinaseGhosh et al. (2003)
FgrTyr kinases expressed in neutrophilsSergeant et al. (2001)
PKCzProtein kinase CζCummings et al. (2002)
SHP-1SH2-containing protein-tyrosine phosphataseFrank et al. (1999)
PP1Protein phosphatase-1Jones and Hannun (2002)
Type1 PI4P5KPhosphatidylinositol 4P-5 kinaseJenkins et al. (1994)
RGS4Regulators of G-protein signaling proteinOuyang et al. (2003)
SPHKSphingosine kinaseDelon et al. (2004)
ARFADP-ribosylation factorManifava et al. (2001)
NSFN-ethylmaleimide-sensitive factor
KinesinVesicular trafficking
Phox 47A cytosolic component of NADPH oxidaseKarathanassis et al. (2002)
PDE4D3cAMP-specific phosphodiesteraseGrange et al. (2000)
  • a Several other proteins were also found to be associated with PA-affinity beads.