Table II.

Effects of various flavonoids on genistein transport

Plasma membrane vesicles were incubated with 50 μm genistein and 5 mm MgATP in the absence (control) or presence of 250 μm of the flavonoids indicated. Values shown are mean ± sd of three replicates, and asterisks indicate a statistically significant difference compared to the +MgATP control. **, P < 0.01; *, P < 0.05.

CompoundSubstance ClassGenistein Uptake
%
Control100
DaidzeinIsoflavone29.0 ± 6.5**
Biochanin AIsoflavone32.1 ± 4.1**
FormononetinIsoflavone29.7 ± 6.3**
NaringeninFlavanone88.9 ± 13.7
KaempferolFlavonol74.0 ± 7.7
Genistin7-O-glucoside of genistein55.9 ± 5.4*
Daidzin7-O-glucoside of daidzein88.4 ± 9.6
Naringin7-O-glucoside of naringenin89.5 ± 10.7
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