Sequences of putative PTS motifs in MVA pathway enzymes
At, A. thaliana; Hs, H. sapiens; *, no consensus PTS1 motif; **, no consensus PTS2 motif.
| Protein Name | PTS1 Motif | Organism | Accession No. |
|---|---|---|---|
| Acetoacetyl-CoA thiolase | SAL | At | NM_124146 |
| QKL | Hs | NM_000019 | |
| Phosphomevalonate kinase | * | At | NM_102927 |
| SRL | Hs | BC007694 | |
| IPP isomerase | HKL | At (IPI1) | NM_121649 |
| HKL | At (IPI2) | NM_111146 | |
| YRM | Hs | AF271720 | |
| PTS2 Motif | |||
| HMG-CoA synthase | SIKTFLMQL | At | NM_117251 |
| SVKTNLMQL | Hs | BC000297 | |
| Mevalonate kinase | KIILAGEHA | At | NM_180753 |
| KVILHGEHA | Hs | M88468 | |
| Mevalonate-PP decarboxylase | SVTLDPDHL | At | NM_129427 |
| SVTLHQDQL | Hs | U49260 | |
| IPP isomerase | ** | At (IPI1) | NM_121649 |
| ** | At (IPI2) | NM_111146 | |
| HLDKQQVQL | Hs | AF271720 | |
| Consensus PTS1 | (S/C/A)(K/R/H)(L/M) | ||
| Consensus PTS2 | (R/K)(L/V/I)X5(H/Q)(L/A) |